Published Studies
These case studies highlight the clinical utility of the Autoimmune Brain Panel™ in patients with complex neuropsychiatric presentations. In each case, test results helped identify underlying immune dysfunction and assisted in guiding targeted treatment ─ leading to symptom improvement or resolution.
Case Study #1:
Autoimmune-induced neuropsychiatric symptoms in an 8-year-old female
Antibiotic treatment leads to resolution of multiple neurologic and psychiatric symptoms
Presenting Symptoms: 8-year-old girl with abrupt onset of obsessive-compulsive behaviors, vocal tics, poor concentration, sensory/motor abnormalities, emotional lability, regression, aggression, and dysgraphia. Parents report urinary and sleep problems.
Course of Illness: Relapsing and remitting symptoms with improvement after 2-3 days of azithromycin.
Previous Diagnosis: Anxiety, OCD, unspecified disorder of immune mechanism
Medical History: Significant for two recent streptococcal infections with high fever, sore throat, sinus pain and cough. History of frequent ear infections, sinus infections and idiopathic fevers.
Treatment: Azithromycin with rapid symptom improvement.
Status: All symptoms resolved. Returned to baseline after 2-3 days of treatment.
Case Study #2:
Gradual onset of tics and severe cognitive regression in 20-year-old male
Initially diagnosed with bipolar disorder, testing reveals immune-mediated condition
Presentation: 20-year-old male with gradual onset of tics, inability to concentrate, sensory abnormalities, emotional lability, severe cognitive regression, separation anxiety, developmental regression, sleep disturbances, handwriting disturbance and aggressiveness.
Previous Diagnoses: Unspecified bipolar disorders
Previous Lab Results: Positive for Lyme disease, Babesia, and Rickettsia
Medical History: Rocky Mountain Spotted Fever, multiple ear and strep infections throughout childhood, known immunodeficiency.
Treatment: Plasmapheresis followed by multiple IVIg treatments.
Status: Overall cognitive abilities improved, with mother reporting patient’s math skills returned after many years.
