Cunningham Panel of Tests
There are a series of five (5) assays in the Cunningham Panel. Four of these clinical assays or tests include enzyme-linked immunosorbent assays (ELISAs) to measure antibody titers against four neuronal antigens present in the brain; the neuronal antigens include:
- dopamine receptor D1
- dopamine receptor D2
A fifth assay is used to quantify calcium/calmodulin-dependent protein kinase activity using a neuronal cell line to test for functional signaling antibodies against human neuronal cells. In the case of each analysis, the measured amounts from the assays are compared to normal control values; the normal control values are obtained from non-PANDAS subjects of similar ages using the same assays.
The values from these five assays performed in duplicate and triplicate, are reported in the Patient Profile Report compared with a normal control range. Assay test values above the normal range are reported. An integrated summary of the results is reported as a relative “risk” of PANDAS/PANS scale based on the group of test values compared to normal ranges and means. The relative risk scale includes the designation of:
- PANDAS/PANS NOT LIKELY
- PANDAS/PANS LIKELY
- PANDAS/PANS HIGHLY LIKELY
PANDAS and PANS diagnoses are based upon defined clinical characteristics. The Cunningham Panel tests for autoantibodies directed against specific neurologic antigens and receptors, and measures the state of the stimulated immune system against HUMAN neuronal cell lines at a single point in time. The results from the Cunningham Panel are provided to the physician as an aid in their diagnosis of PANDAS or PANS. There are treatments that are known to affect the test values of this panel, which include: recent treatment by intravenous immunoglobulin (IVIG), plasmapheresis or plasma exchange, and steroid treatment.
The patient report will include the actual data from each of these above 5 tests performed in duplicate and triplicate. A mock copy of the Patient Profile Report can be viewed at the link below.
Sample Patient Report
For more information about research in the Cunningham Laboratory at the University of Oklahoma, you can click on the link below:Cunningham Research